Street-smart Nathan Drake is recruited by seasoned treasure hunter Victor “Sully” Sullivan to recover a fortune amassed by Ferdinand Magellan, and lost 500 years ago by the House of Moncada.

Joe meets a mother who can contact spirits when suffocating. Her daughter is dying when Joe helps the mother spiritually contact the daughter and save her. Unfortunately, the spirit in the daughter’s body is now that of Joe’s dead wife.

A scientific expedition investigating the outbreak of an unknown viral epidemic on an island in the south Pacific battles with a giant alien spider in the jungle.