For twenty years, Charlie Swift has been a fixer and hitman for a mob boss named Stan. After a rival boss puts a hit on Stan and his crew, Charlie is the sole survivor. Charlie decides to avenge his friend.

Foul-mouthed mutant mercenary Wade Wilson (a.k.a. Deadpool), brings together a team of fellow mutant rogues to protect a young boy with supernatural abilities from the brutal, time-traveling cyborg Cable.