Former musician and gunslinger El Mariachi arrives at a small Mexican border town after being away for a long time. His past quickly catches up with him and he soon gets entangled with the local drug kingpin Bucho and his gang.

Just out of prison, Billy Walker returns to El Paso to find his mom dying of liver failure but low on the transplant list. However, the border offers other, darker options.

Violence and mayhem ensue after a hunter stumbles upon a drug deal gone wrong and more than two million dollars in cash near the Rio Grande.